Deregulation of microRNA expression in thyroid neoplasias

被引：116

作者：

Pallante, Pierlorenzo ^{[1
]}

Battista, Sabrina ^{[1
]}

Pierantoni, Giovanna Maria ^{[1
]}

Fusco, Alfredo ^{[1
]}

机构：

[1] Univ Naples Federico II, Ist Endocrinol & Oncol Sperimentale IEOS G Salvat, CNR, Dipartimento Med Mol & Biotecnol Med, I-80131 Naples, Italy

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2014年 / 10卷 / 02期

关键词：

NF-KAPPA-B; ESTROGEN-RECEPTOR-ALPHA; DOWN-REGULATION PLAYS; CARCINOMA-CELL-LINES; BREAST-CANCER; DIFFERENTIAL EXPRESSION; PROSTATE CARCINOMA; TUMOR-SUPPRESSOR; UP-REGULATION; IN-VIVO;

D O I：

10.1038/nrendo.2013.223

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

MicroRNAs (miRNAs) have emerged as a class of powerful gene expression regulators. Acting at the post-transcriptional level, miRNAs modulate the expression of at least one-third of the mRNAs that are encoded by the human genome. The expression of a single gene can be regulated by several miRNAs, and every miRNA has more than one target gene. Thus, the miRNA regulatory circuit, which affects essential cellular functions, is of enormous complexity. Moreover, a fundamental role for miRNAs has been determined in the onset and progression of human cancers. Here, we summarize the main alterations in miRNA expression that have been identified in thyroid neoplasias and examine the mechanisms through which miRNA deregulation might promote thyroid cell transformation. We also discuss how the emerging knowledge on miRNA deregulation could be harnessed for the diagnosis and treatment of thyroid neoplasias.

引用

页码：88 / 101

页数：14

共 215 条

[1]

MicroRNA Profiling of Sporadic and Hereditary Medullary Thyroid Cancer Identifies Predictors of Nodal Metastasis, Prognosis, and Potential Therapeutic Targets [J].