Antimicrobial and anti-lipase activity of quercetin and its C2-C163-O-acyl-esters

被引:83
作者
Gatto, MT
Falcocchio, S
Grippa, E
Mazzanti, G
Battinelli, L
Nicolosi, G
Lambusta, D
Saso, L
机构
[1] Univ Roma La Sapienza, Dept Pharmacol Nat Subst & Gen Physiol, I-00185 Rome, Italy
[2] CNR, Ist Studio Sostanze Nat Interesse Alimentare & Ch, I-95028 Valverde, CT, Italy
关键词
D O I
10.1016/S0968-0896(01)00275-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neither quercetin (Q). nor 3-Ow-acylquercetines, up to 100 mug/mL, had any significant activity on selected gram-positive strains (Staphylococcus aureus, Bacillus subtilis, Listeria ivanovi, Listeria monocytogenes, Listeria serligeri), gram-negative strains (Escherichia coli, Shigella flexneri, Shigella sonnei, Salmonella enteritidis, Salmonella tiphymurium) and yeasts (Candida albicans and Candida glabrata). In addition, we confirmed the known anti-HIV activity of Q (80% inhibition at 40 muM), which might depend on the free hydroxyl in the C-3 position, as suggested by the lack of activity of the 3-O-acylquercetines. Finally, we described an interesting inhibitory activity on Candida rugosa lipase by Q (IC16 = 10(-4) M) and its esters (3-O-acylquercetines) which, in vivo, could play an important role against lipase producing microorganisms. In particular, 3-O-acyl-quercetines, being more active (IC16 = 10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae, and deserve to be studied further. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
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页码:269 / 272
页数:4
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