Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-1 protease

被引：46

作者：

Min, BS

Jung, HJ

Lee, JS

Kim, YH

Bok, SH

Ma, CM

Nakamura, N

Hattori, M

Bae, K ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon, South Korea

[3] Toyama Med & Pharmaceut Univ, Res Inst Tradit Sinojapanese Med, Toyama, Japan

来源：

PLANTA MEDICA | 1999年 / 65卷 / 04期

关键词：

D O I：

10.1055/s-2006-960792

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 mu g/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data, These active compounds inhibit HIV-1 protease with IC50 values of 5.5 and 8.0 mu M, respectively.

引用

页码：374 / 375

页数：2

共 13 条

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