Relevance of plasma protein binding to antiviral activity and clinical efficacy of inhibitors of human immunodeficiency virus protease

被引:25
作者
Bilello, JA
Drusano, GL
机构
关键词
D O I
10.1093/infdis/173.6.1524
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:1524 / 1525
页数:2
相关论文
共 10 条
[1]   REDUCTION OF THE IN-VITRO ACTIVITY OF A77003, AN INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE, BY HUMAN SERUM ALPHA(1) ACID GLYCOPROTEIN [J].
BILELLO, JA ;
BILELLO, PA ;
PRICHARD, M ;
ROBINS, T ;
DRUSANO, GL .
JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (03) :546-551
[2]   EFFICACY OF CONSTANT INFUSION OF A-77003, AN INHIBITOR OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) PROTEASE, IN LIMITING ACUTE HIV-1 INFECTION IN-VITRO [J].
BILELLO, JA ;
BILELLO, PA ;
KORT, JJ ;
DUDLEY, MN ;
LEONARD, J ;
DRUSANO, GL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (11) :2523-2527
[3]  
BILELLO JA, 1995, 2 NAT C HUM RETR REL
[4]   IN-VIVO EMERGENCE OF HIV-1 VARIANTS RESISTANT TO MULTIPLE PROTEASE INHIBITORS [J].
CONDRA, JH ;
SCHLEIF, WA ;
BLAHY, OM ;
GABRYELSKI, LJ ;
GRAHAM, DJ ;
QUINTERO, JC ;
RHODES, A ;
ROBBINS, HL ;
ROTH, E ;
SHIVAPRAKASH, M ;
TITUS, D ;
YANG, T ;
TEPPLER, H ;
SQUIRES, KE ;
DEUTSCH, PJ ;
EMINI, EA .
NATURE, 1995, 374 (6522) :569-571
[5]   A SHORT-TERM STUDY OF THE SAFETY, PHARMACOKINETICS, AND EFFICACY OF RITONAVIR, AN INHIBITOR OF HIV-1 PROTEASE [J].
DANNER, SA ;
CARR, A ;
LEONARD, JM ;
LEHMAN, LM ;
GUDIOL, F ;
GONZALES, J ;
RAVENTOS, A ;
RUBIO, R ;
BOUZA, E ;
PINTADO, V ;
AGUADO, AG ;
DELOMAS, JG ;
DELGADO, R ;
BORLEFFS, JCC ;
HSU, A ;
VALDES, JM ;
BOUCHER, CAB ;
COOPER, DA ;
GIMENO, C ;
CLOTET, B ;
TOR, J ;
FERRER, E ;
MARTINEZ, PL ;
MORENO, S ;
ZANCADA, G ;
ALCAMI, J ;
NORIEGA, AR ;
PULIDO, F ;
GLASSMAN, HN .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (23) :1528-1533
[6]   EFFECT OF SATURABLE SERUM-PROTEIN BINDING ON THE PHARMACOKINETICS OF UNBOUND CEFONICID IN HUMANS [J].
DUDLEY, MN ;
SHYU, WC ;
NIGHTINGALE, CH ;
QUINTILIANI, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (04) :565-569
[7]   A RANDOMIZED TRIAL OF THE ACTIVITY AND SAFETY OF RO-24-7429 (TAT ANTAGONIST) VERSUS NUCLEOSIDE FOR HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].
HAUBRICH, RH ;
FLEXNER, C ;
LEDERMAN, MM ;
HIRSCH, M ;
PETTINELLI, CP ;
GINSBERG, R ;
LIETMAN, P ;
HAMZEH, FM ;
SPECTOR, SA ;
RICHMAN, DD ;
HAMMER, S ;
COOLEY, T ;
GULICK, R ;
SULLIVAN, M ;
SPINA, C ;
FRASER, A ;
LATHEY, J ;
BASSIAKOS, Y ;
CHANCE, M ;
DROBNES, C ;
CORUELL, E ;
GRUE, L ;
RAINES, C ;
KUWAHARA, S ;
MCPHERSON, J .
JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (05) :1246-1252
[8]   WEAK BINDING OF VX-478 TO HUMAN PLASMA-PROTEINS AND IMPLICATIONS FOR ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS THERAPY [J].
LIVINGSTON, DJ ;
PAZHANISAMY, S ;
PORTER, DJT ;
PARTALEDIS, JA ;
TUNG, RD ;
PAINTER, GR .
JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (05) :1238-1245
[9]   EFFECT OF PROTEIN-BINDING ON ANTIBIOTIC-ACTIVITY INVIVO [J].
MERRIKIN, DJ ;
BRIANT, J ;
ROLINSON, GN .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 11 (03) :233-238
[10]  
STEIN DS, 1996, IN PRESS AIDS, P10