The pharmacological treatment of cachexia

被引:29
作者
Argilés, JM [1 ]
Almendro, V [1 ]
Busquets, S [1 ]
López-Soriano, FJ [1 ]
机构
[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Canc Res Grp, E-08071 Barcelona, Spain
关键词
cachexia; cancer; AIDS; chronic heart failure; anorexia; tumor therapy;
D O I
10.2174/1389450043490505
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities such as glucose intolerance, fat depletion, and muscle protein catabolism among others. The aim of the present article is to review the different therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure.
引用
收藏
页码:265 / 277
页数:13
相关论文
共 172 条
[1]  
ADAMS R, 1981, ASTHENIA PRINCIPLES, P341
[2]   The effects of enalapril-digoxin-diuretic combination therapy on nutritional and anthropometric indices in chronic congestive heart failure: preliminary findings in cardiac cachexia [J].
Adigun, AQ ;
Ajayi, AAL .
EUROPEAN JOURNAL OF HEART FAILURE, 2001, 3 (03) :359-363
[3]   Randomized clinical trial of adenosine 5′-triphosphate in patients with advanced non-small-cell lung cancer [J].
Agteresch, HJ ;
Dagnelie, PC ;
van der Gaast, A ;
Stijnen, T ;
Wilson, JH .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (04) :321-328
[4]   Beneficial effects of adenosine triphosphate on nutritional status in advanced lung cancer patients: A randomized clinical trial [J].
Agteresch, HJ ;
Rietveld, T ;
Kerkhofs, LGM ;
van den Berg, JWO ;
Wilson, JHP ;
Dagnelie, PC .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (02) :371-378
[5]   Leptin role in advanced lung cancer.: A mediator of the acute phase response or a marker of the status of nutrition? [J].
Alemán, MR ;
Santolaria, F ;
Batista, N ;
de la Vega, MJ ;
González-Reimers, E ;
Milena, A ;
Llanos, M ;
Gómez-Sirvent, JL .
CYTOKINE, 2002, 19 (01) :21-26
[6]   How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH [J].
Anker, SD ;
Coats, AJS .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2002, 86 (2-3) :123-130
[7]   Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study [J].
Anker, SD ;
Negassa, A ;
Coats, AJS ;
Afzal, R ;
Poole-Wilson, PA ;
Cohn, JN ;
Yusuf, S .
LANCET, 2003, 361 (9363) :1077-1083
[8]   The syndrome of cardiac cachexia [J].
Anker, SD ;
Sharma, R .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2002, 85 (01) :51-66
[9]   EFFECT OF OMEGA-3-FATTY-ACIDS ON RECTAL MUCOSAL CELL-PROLIFERATION IN SUBJECTS AT RISK FOR COLON CANCER [J].
ANTI, M ;
MARRA, G ;
ARMELAO, F ;
BARTOLI, GM ;
FICARELLI, R ;
PERCESEPE, A ;
DEVITIS, I ;
MARIA, G ;
SOFO, L ;
RAPACCINI, GL ;
GENTILONI, N ;
PICCIONI, E ;
MIGGIANO, G .
GASTROENTEROLOGY, 1992, 103 (03) :883-891
[10]   THE ROLE OF CYTOKINES IN MUSCLE WASTING - ITS RELATION WITH CANCER CACHEXIA [J].
ARGILES, JM ;
GARCIAMARTINEZ, C ;
LLOVERA, M ;
LOPEZSORIANO, FJ .
MEDICINAL RESEARCH REVIEWS, 1992, 12 (06) :637-652