Effects of highly active antiretroviral therapy on thymical reconstitution of CD4 T lymphocytes in vertically HIV-infected children

被引：19

作者：

Correa, R ^{[1
]}

Munoz-Fernández, A ^{[1
]}

机构：

[1] Hosp Gen Univ Gregorio Maranon, Dept Immunol, Madrid 28007, Spain

来源：

AIDS | 2002年 / 16卷 / 08期

关键词：

D O I：

10.1097/00002030-200205240-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4 T-cell percentages, viral load and thymic function measured as T-cell receptor rearrangement excision circle (TREC) levels were determined every 2-3 months in six treated HIV-infected children for 4 years. All children experienced a marked increase in CD4 cell count after therapy, accompanied by a concomitantly marked increase in TREC levels. In children, the decrease in viral load caused by antiviral therapy leads to an increase in CD4 T cells, mainly because of a recovery in the thymic production of new T cells.

引用

页码：1181 / 1183

页数：3

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