Resting state fMRI in Alzheimer's disease: beyond the default mode network

被引:512
作者
Agosta, Federica [1 ]
Pievani, Michela [1 ,2 ]
Geroldi, Cristina [2 ]
Copetti, Massimiliano [3 ]
Frisoni, Giovanni B. [2 ]
Filippi, Massimo [1 ]
机构
[1] Univ Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, Div Neurosci,San Raffaele Sci Inst, I-20132 Milan, Italy
[2] IRCCS Ctr San Giovanni di Dio Fatebenefratelli, Brescia, Italy
[3] IRCCS Osped Casa Sollievo Sofferenza, Biostat Unit, Foggia, Italy
关键词
Alzheimer's disease; Mild cognitive impairment; Functional MRI (fMRI); Resting state fMRI; MILD COGNITIVE IMPAIRMENT; INDEPENDENT COMPONENT ANALYSIS; POSTERIOR CINGULATE CORTEX; FUNCTIONAL CONNECTIVITY; FDG PET; HIPPOCAMPAL ACTIVATION; MATTER HYPOMETABOLISM; BRAIN-FUNCTION; DEMENTIA; MEMORY;
D O I
10.1016/j.neurobiolaging.2011.06.007
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
030301 [社会学]; 100201 [内科学];
摘要
Using resting state (RS) functional magnetic resonance imaging (fMRI), the connectivity patterns of the default mode (DMN), frontoparietal, executive, and salience networks were explored in 13 Alzheimer's disease (AD) patients, 12 amnestic mild cognitive impairment (aMCI) patients, and 13 healthy controls. Compared with controls and aMCI, AD was associated with opposing connectivity effects in the DMN (decreased) and frontal networks (enhanced). The only RS abnormality found in aMCI patients compared with controls was a precuneus connectivity reduction in the DMN. RS fMRI group differences were only partly related to gray matter atrophy. In AD patients, the mean executive network connectivity was positively associated with frontal-executive and language neuropsychological scores. These results suggest that AD is associated with an alteration of large-scale functional brain networks, which extends well beyond the DMN. In AD, the limited resources of the DMN may be paralleled, in an attempt to maintain cognitive efficiency, by an increased prefrontal connectivity. A medial parietal RS fMRI signal change seems to be present since the early phase of AD. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:1564 / 1578
页数:15
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