A radical mediated approach to the core structure of huperzine A

被引：19

作者：

Ward, J ^{[1
]}

Caprio, V ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland 1, New Zealand

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 04期

关键词：

huperzine A; pyridylmethyl radicals; selenation; radical cyclisation;

D O I：

10.1016/j.tetlet.2005.11.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the core structure of huperzine A by cyclisation of 2-pyridylmethyl radicals is described. (2-Methylpyridin-3-yl)cyclohexenols are directly selenated at the benzylic position by deprotonation/selenation and the products undergo either 5-exo-trig or 6-exo-trig radical cyclisations giving access to hexahydroindenopyridines and the bicyclo[3.3.1]nonane core of huperzine A, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：553 / 556

页数：4

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