Analyzing genes using closing and replicating circles

被引：63

作者：

Nilsson, M ^{[1
]}

Dahl, F ^{[1
]}

Larsson, C ^{[1
]}

Gullberg, M ^{[1
]}

Stenberg, J ^{[1
]}

机构：

[1] Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, SE-75185 Uppsala, Sweden

来源：

TRENDS IN BIOTECHNOLOGY | 2006年 / 24卷 / 02期

关键词：

D O I：

10.1016/j.tibtech.2005.12.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

During the past two years, significant breakthroughs have been achieved in genetic analyses through the application of technologies based on analytical DNA-circularization reactions. Padlock probes and molecular inversion probes have enabled parallel, high-throughput single nucleotide polymorphism (SNP) genotyping at increased scales, whereas, at the other end of the analysis spectrum, DNA molecules in individual cells have been genotyped, in situ, using padlock probes and rolling-circle amplification (RCA). This review describes the recent developments in the technologies that use specific DNA circularization, coupled to DNA amplification through PCR or rolling-circle amplification, and addresses the great potential of these tools.

引用

页码：83 / 88

页数：6

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