Imaging in primary progressive aphasia

被引:52
作者
Abe, K [1 ]
Ukita, H [1 ]
Yanagihara, T [1 ]
机构
[1] OSAKA UNIV HOSP,REHABIL SERV,OSAKA 553,JAPAN
关键词
aphasia; primary progressive; magnetic resonance imaging; single photon emission computed tomography;
D O I
10.1007/s002340050466
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Primary progressive aphasia (PPA) presents with aphasia, with or without other miner cognitive dysfunction. We report five patients with PPA to show the correlation between their clinical signs and imaging findings. The patients can be divided into these with nonfluent (group 1) and those with fluent (group 2) aphasia. The characteristic speech impairment was bradylalia in group 1 and word amnesia in group 2. Impairment of comprehension was common but mild in both groups. On MRI, patients in group 1 showed predominantly left frontal and perisylvian atrophy with reduced uptake in the same region on single photon emission computed tomography (SPECT) using technetium-99m hexamethyl propylenoamine oxime (Te-99m HMPAO). Patients in group 2 showed left temporal atrophy involving the superior, middle and inferior temporal gyri, hippocampus and parahippocampal gyrus on MRI and reduced uptake in the same region on SPECT. These findings correlated well with the functional anatomy of speech impairment.
引用
收藏
页码:556 / 559
页数:4
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