Amphimic acids and related long-chain fatty acids as DNA topoisomerase I inhibitors from an Australian sponge, Amphimedon sp: Isolation, structure, synthesis, and biological evaluation

被引：69

作者：

Nemoto, T ^{[1
]}

Yoshino, G ^{[1
]}

Ojika, M ^{[1
]}

Sakagami, Y ^{[1
]}

机构：

[1] NAGOYA UNIV,GRAD SCH BIOAGR SCI,NAGOYA,AICHI 46401,JAPAN

来源：

TETRAHEDRON | 1997年 / 53卷 / 49期

关键词：

D O I：

10.1016/S0040-4020(97)10099-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several C-27-C-30 unsaturated fatty acids have been isolated from an Australian sponge, Amphimedon sp., as human DNA topoisomerase I inhibitors. Three of them, amphimic acids A (1)-C (3), are unusual fatty acids possessing a cyclopropylidene group, and one is a new C-30 fatty acid 4. Their structures were elucidated by spectroscopic analysis and chemical degradation. The enantioselective synthesis of 1 was carried out to determine the absolute configuration of amphimic acids. The inhibitory activity of DNA topoisomerase I was evaluated for these natural products and synthetic derivatives. (C) 1997 Elsevier Science Ltd.

引用

页码：16699 / 16710

页数：12

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