Protein domain analysis in the era of complete genomes

被引：49

作者：

Copley, RR

Doerks, T

Letunic, I

Bork, P

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

FEBS LETTERS | 2002年 / 513卷 / 01期

关键词：

protein domains; genome analysis; evolution; sequence analysis;

D O I：

10.1016/S0014-5793(01)03289-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Domains present one of the most useful levels at which to understand protein function, and domain family-based analysis has had a profound impact on the study of individual proteins. Protein domain discovery has been progressing steadily over the past 30 years. What are the realistically achievable goals of sequence-based domain analysis, and how far off are they for the sequences encoded in eukaryotic genomes? Here we address some of the issues involved in better coverage of sequence-based domain annotation, and the integration of these results within the wider context of genomes, structures and function. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：129 / 134

页数：6

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