Adjusted prognostic association of depression following myocardial infarction with mortality and cardiovascular events: individual patient data meta-analysis

被引：191

作者：

Meijer, A. ^{[1
]}

Conradi, H. J. ^{[2
]}

Bos, E. H. ^{[1
]}

Anselmino, M. ^{[3
]}

Carney, R. M. ^{[4
]}

Denollet, J. ^{[5
]}

Doyle, F. ^{[6
]}

Freedland, K. E. ^{[4
]}

Grace, S. L. ^{[7
,8
]}

Hosseini, S. H. ^{[9
]}

Lane, D. A. ^{[10
]}

Pilote, L. ^{[11
,12
]}

Parakh, K. ^{[13
]}

Rafanelli, C. ^{[14
]}

Sato, H. ^{[15
]}

Steeds, R. P. ^{[16
]}

Welin, C. ^{[17
]}

de Jonge, P. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychiat Epidemiol, NL-9713 GZ Groningen, Netherlands

[2] Univ Amsterdam, Dept Clin Psychol, NL-1018 WB Amsterdam, Netherlands

[3] Univ Turin, Dept Internal Med, San Giovanni Battista Hosp, Div Cardiol, Turin, Italy

[4] Washington Univ, Dept Psychiat, St Louis, MO USA

[5] Tilburg Univ, Ctr Res Psychol Somat Dis, NL-5000 LE Tilburg, Netherlands

[6] Royal Coll Surgeons Ireland, Div Populat Hlth Sci Psychol, Dublin 2, Ireland

[7] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 2R7, Canada

[8] Univ Hlth Network, Toronto, ON, Canada

[9] Mazandaran Univ Med Sci, Dept Psychiat, Psychiat & Sci Behav Res Ctr, Sari, Iran

[10] Univ Birmingham, Ctr Cardiovasc Sci, Birmingham, W Midlands, England

[11] McGill Univ, Ctr Hlth, Div Gen Internal Med, Montreal, PQ, Canada

[12] McGill Univ, Ctr Hlth, Div Clin Epidemiol, Montreal, PQ, Canada

[13] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[14] Univ Bologna, Dept Psychol, Bologna, Italy

[15] Kwansei Gakuin Univ, Sch Human Welf Studies, Nishinomiya, Hyogo, Japan

[16] Queen Elizabeth Hosp, Dept Cardiol, Birmingham B15 2TH, W Midlands, England

[17] Univ Gothenburg, Sahlengrenska Acad, Inst Hlth & Care Sci, Gothenburg, Sweden

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2013年 / 203卷 / 02期

基金：

日本学术振兴会;

关键词：

CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; VALIDATED PREDICTION MODEL; RISK-FACTOR; SELF-EFFICACY; CARDIAC RISK; INVESTIGATING HETEROGENEITY; 6-MONTH MORTALITY; MAJOR DEPRESSION; REGRESSION-MODEL;

D O I：

10.1192/bjp.bp.112.111195

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background The association between depression after myocardial infarction and increased risk of mortality and cardiac morbidity may be due to cardiac disease severity. Aims To combine original data from studies on the association between post-infarction depression and prognosis into one database, and to investigate to what extent such depression predicts prognosis independently of disease severity. Method An individual patient data meta-analysis of studies was conducted using multilevel, multivariable Cox regression analyses. Results Sixteen studies participated, creating a database of 10 175 post-infarction cases. Hazard ratios for post-infarction depression were 1.32 (95% CI 1.26-1.38, P<0.001) for all-cause mortality and 1.19 (95% CI 1.14-1.24, P<0.001) for cardiovascular events. Hazard ratios adjusted for disease severity were attenuated by 28% and 25% respectively. Conclusions The association between depression following myocardial infarction and prognosis is attenuated after adjustment for cardiac disease severity. Still, depression remains independently associated with prognosis, with a 22% increased risk of all-cause mortality and a 13% increased risk of cardiovascular events per standard deviation in depression z-score.

引用

页码：90 / 102

页数：13

共 95 条

[1]

BIOBEHAVIORAL VARIABLES AND MORTALITY OR CARDIAC-ARREST IN THE CARDIAC-ARRHYTHMIA PILOT-STUDY (CAPS) [J].