Systemic Lupus Erythematosus in a Multiethnic US Cohort (LUMINA): LXI. Value of C-Reactive Protein as a Marker of Disease Activity and Damage

被引:33
作者
Bertoli, Ana M.
Vila, Luis M. [1 ]
Reveille, John D. [2 ]
Alarcon, Graciela S. [3 ]
机构
[1] Univ Puerto Rico, Div Rheumatol, Dept Med, San Juan, PR 00936 USA
[2] Univ Texas Hlth Sci Ctr Houston, Div Rheumatol & Clin Immunogenet, Houston, TX USA
[3] Univ Alabama, Jane Knight Lowe Chair Med Rheumatol, Birmingham, AL USA
关键词
SYSTEMIC LUPUS ERYTHEMATOSUS; C-REACTIVE PROTEIN; DISEASE ACTIVITY; DISEASE DAMAGE;
D O I
10.3899/jrheum.080175
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To determine whether C-reactive protein (CRP) measured by a high sensitivity (hs) assay is 11 Surrogate marker of disease activity and damage in systemic lupus erythematosus (SLE). Methods. Five hundred eighty-eight patients with SLE participating in a multiethnic cohort (Hispanic, African American, and Caucasian) were studied. Disease activity was measured with the Systemic Lupus Activity Measure-Revised (SLAM-R) and damage with the Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (SDI). hs-CRP was measured by immunometric assay. Disease activity and hs-CRP were measured at enrollment and damage accrual at last visit. The association of hs-CRP with the SLAM-R and SDI was examined by univariable (Pearson's correlation) and multivariable (linear regression) analyses. The association of hs-CRP and each individual domain of the SLAM-R and SDI was examined by Spearman's correlation. Results. hs-CRP was associated with the SLAM-R in the Univariable (r = 0.35, p < 0.001) and multivariable (t = 7.11, coefficient beta = 0.27, p < 0.001) analyses. It also correlated with the constitutional, eye, pulmonary, gastrointestinal, neuromotor, and laboratory domains of the SLAM-R. hs-CRP was associated with the SDI (r = 0.12, p = 0.004) in the univariable analysis but not in the multivariable analysis. When the individual domains of the SDI were analyzed, hs-CRP correlated with the renal, pulmonary, cardiovascular, musculoskeletal, and diabetes domains. Conclusion. hs-CRP was associated with disease activity but not with overall damage accrual; however, it correlated with specific domains of the damage index. hs-CRP may be useful to monitor the course of the disease and predict its intermediate outcome, but longitudinal studies with serial hs-CRP measurements are necessary to define its clinical value. (First Release Nov 1 2008; J Rheumatol 2008;35:2355-8; doi: 10.3899/jrheum.080175)
引用
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页码:2355 / 2358
页数:4
相关论文
共 27 条
[1]   Chronic inflammatory autoimmune disorders and atherosclerosis [J].
Abu-Raya, S. ;
Abou-Raya, A. ;
Naim, A. ;
Abuelkheir, H. .
AUTOIMMUNITY, PT C: THE MOSAIC OF AUTOIMMUNITY, 2007, 1107 :56-67
[2]   Systemic lupus erythematosus in three ethnic groups.: XX.: Damage as a predictor of further damage [J].
Alarcón, GS ;
Roseman, JM ;
McGwin, G ;
Uribe, A ;
Bastian, HM ;
Fessler, BJ ;
Baethge, BA ;
Friedman, AW ;
Reveille, JD .
RHEUMATOLOGY, 2004, 43 (02) :202-205
[3]  
Alarcón GS, 1998, ARTHRITIS RHEUM-US, V41, P1173, DOI 10.1002/1529-0131(199807)41:7<1173::AID-ART5>3.0.CO
[4]  
2-A
[5]  
Alarcón GS, 2001, ARTHRITIS RHEUM, V44, P2797, DOI 10.1002/1529-0131(200112)44:12<2797::AID-ART467>3.0.CO
[6]  
2-9
[7]   High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk [J].
Barnes, EV ;
Narain, S ;
Naranjo, A ;
Shuster, J ;
Segal, MS ;
Sobel, ES ;
Armstrong, AE ;
Santiago, BE ;
Reeves, WH ;
Richards, HB .
LUPUS, 2005, 14 (08) :576-582
[8]  
Dessein PH, 2004, J RHEUMATOL, V31, P1095
[9]   DECREASED AUTOANTIBODY LEVELS AND ENHANCED SURVIVAL OF (NZB X NZW) F(1) MICE TREATED WITH C-REACTIVE PROTEIN [J].
DUCLOS, TW ;
ZLOCK, LT ;
HICKS, PS ;
MOLD, C .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1994, 70 (01) :22-27
[10]  
GABAY C, 1993, J RHEUMATOL, V20, P815