Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

被引：432

作者：

Gazit, R

Gruda, R

Elboim, M

Arnon, TI

Katz, G

Achdout, H

Hanna, J

Qimron, U

Landau, G

Greenbaum, E

Zakay-Rones, Z

Porgador, A

Mandelboim, O ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel

[2] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Canc Res Ctr, IL-84105 Beer Sheva, Israel

[4] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Virol, IL-91120 Jerusalem, Israel

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 05期

基金：

以色列科学基金会;

关键词：

D O I：

10.1038/ni1322

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

引用

页码：517 / 523

页数：7

共 47 条

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