Myostatin: more than just a regulator of muscle mass

被引：97

作者：

Argiles, Josep M. ^{[1
,2
]}

Orpi, Marcel ^{[1
]}

Busquets, Silvia ^{[1
,2
]}

Lopez-Soriano, Francisco J. ^{[1
,2
]}

机构：

[1] Univ Barcelona, Fac Biol, Canc Res Grp, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

[2] Univ Barcelona, Inst Biomed, E-08028 Barcelona, Spain

来源：

DRUG DISCOVERY TODAY | 2012年 / 17卷 / 13-14期

关键词：

FOLLISTATIN-RELATED GENE; BETA SUPERFAMILY MEMBER; CANCER CACHEXIA MICE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; DEACETYLASE INHIBITORS; DYSTROPHIC MICE; MYOBLAST TRANSPLANTATION; INSULIN SENSITIVITY; PROTEOLYTIC SYSTEM;

D O I：

10.1016/j.drudis.2012.02.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The presence of sufficient skeletal muscle mass is of paramount importance for body function and the myostatin cascade is known to inhibit muscle growth in mammals. In addition, myostatin seems to have an important role in the cross-talk between skeletal muscle and adipose tissue and is involved in insulin sensitivity. In this article we highlight the latest developments related to the myostatin system, emphasizing therapeutic implications for wasting diseases and also the involvement of the system in other organs, in addition to skeletal muscle, such as heart or adipose tissue. Moreover, we highlight the possible role of the myostatin system in the cross-talk between skeletal muscle and adipose tissue, an important aspect that deserves consideration in wasting diseases.

引用

页码：702 / 709

页数：8

共 95 条

[1] The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity [J].

Akpan, I. ;

Goncalves, M. D. ;

Dhir, R. ;

Yin, X. ;

Pistilli, E. E. ;

Bogdanovich, S. ;

Khurana, T. S. ;

Ucran, J. ;

Lachey, J. ;

Ahima, R. S. .

INTERNATIONAL JOURNAL OF OBESITY, 2009, 33 (11) :1265-1273

[2] Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice [J].

Allen, David L. ;

Cleary, Allison S. ;

Speaker, Kristin J. ;

Lindsay, Sarah F. ;

Uyenishi, Jill ;

Reed, Jason M. ;

Madden, Molly C. ;

Mehan, Ryan S. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 294 (05) :E918-E927

[3] Structure of the ternary signaling complex of a TGF-β superfamily member [J].

Allendorph, George P. ;

Vale, Wylie W. ;

Choe, Senyon .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (20) :7643-7648

[4] The regulation and action of myostatin as a negative regulator of muscle development during avian embryogenesis [J].

Amthor, H ;

Huang, RJ ;

McKinnell, I ;

Christ, B ;

Kambadur, R ;

Sharma, M ;

Patel, K .

DEVELOPMENTAL BIOLOGY, 2002, 251 (02) :241-257

[5] Lack of myostatin results in excessive muscle growth but impaired force generation [J].

Amthor, Helge ;

Macharia, Raymond ;

Navarrete, Roberto ;

Schuelke, Markus ;

Brown, Susan C. ;

Otto, Anthony ;

Voit, Thomas ;

Muntoni, Francesco ;

Vrbova, Gerta ;

Partridge, Terence ;

Zammit, Peter ;

Bunger, Lutz ;

Patel, Ketan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (06) :1835-1840

[6] Identification of a novel pool of extracellular pro-myostatin in skeletal muscle [J].

Anderson, Sarah B. ;

Goldberg, Alfred L. ;

Whitman, Malcolm .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (11) :7027-7035

[7] Cross-talk between skeletal muscle and adipose tissue:: A link with obesity? [J].

Argilés, JM ;

López-Soriano, J ;

Almendro, V ;

Busquets, S ;

López-Soriano, FJ .

MEDICINAL RESEARCH REVIEWS, 2005, 25 (01) :49-65

[8]

Argiles Josep M, 2009, Curr Opin Support Palliat Care, V3, P263, DOI 10.1097/SPC.0b013e3283311d09

[9]

Argiles Josep M, 2007, Curr Opin Support Palliat Care, V1, P293, DOI 10.1097/SPC.0b013e3282f34738

[10] Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells [J].

Artaza, JN ;

Bhasin, S ;

Magee, TR ;

Reisz-Porszasz, S ;

Shen, RQ ;

Groome, NP ;

Fareez, MM ;

Gonzalez-Cadavid, NF .

ENDOCRINOLOGY, 2005, 146 (08) :3547-3557

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