Diffusion-based tractography in neurological disorders: concepts, applications, and future developments

被引：293

作者：

Ciccarelli, Olga ^{[1
]}

Catani, Marco ^{[2
]}

Johansen-Berg, Heidi ^{[3
]}

Clark, Chris ^{[4
]}

Thompson, Alan ^{[1
]}

机构：

[1] UCL, Inst Neurol, Dept Brain Repair & Rehabil, London WC1E 6BT, England

[2] Kings Coll London, Inst Psychiat, Dept Psychol Med, London WC2R 2LS, England

[3] Univ Oxford, Ctr Funct Magnet Resonance Imaging Brain, Oxford, England

[4] UCL, Inst Child Hlth, London WC1E 6BT, England

来源：

LANCET NEUROLOGY | 2008年 / 7卷 / 08期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/S1474-4422(08)70163-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diffusion-based tractography enables the graphical reconstruction of the white matter pathways in the brain and spinal cord of living humans. This technique has many potential clinical applications, including the investigation of stroke, multiple sclerosis, epilepsy, neurodegenerative diseases, and spinal cord disorders, and it enables hypotheses to be tested that could not previously be considered in living humans. This Review will outline the limitations of tractography, describe its current clinical applications in the most common neurological diseases, and highlight future opportunities.

引用

页码：715 / 727

页数：13

共 134 条

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