Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil

被引：20

作者：

Kabuto, H

Asanuma, M

Nishibayashi, S

Iida, M

Ogawa, N

机构：

[1] Okayama University Medical School,Department of Neuroscience, Institute of Molecular and Cellular Medicine

来源：

NEUROCHEMICAL RESEARCH | 1997年 / 22卷 / 01期

关键词：

transient ischemia; Oren-gedoku-to (TJ15); acetylcholine; muscarinic receptor; serotonin; monoamine metabolism;

D O I：

10.1023/A:1027369119224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

引用

收藏

页码：33 / 36

页数：4

相关论文

共 27 条

[1]

POSTISCHEMIC ALTERATION OF MUSCARINIC ACETYLCHOLINE AND ADENOSINE-A1 BINDING-SITES IN GERBIL BRAIN - PROTECTIVE EFFECTS OF A NOVEL VINCA ALKALOID DERIVATIVE, VINCONATE, AND PENTOBARBITAL USING AN AUTORADIOGRAPHIC STUDY [J].

ARAKI, T ;

KATO, H ;

KOGURE, K .

RESEARCH IN EXPERIMENTAL MEDICINE, 1992, 192 (02) :79-88

[2]

ANTICHOLINESTERASE-INDUCED AMNESIA AND ITS TEMPORAL ASPECTS [J].

DEUTSCH, JA ;

HAMBURG, MD ;

DAHL, H .

SCIENCE, 1966, 151 (3707) :221-&

[3]

EFFECTS OF LONG-TERM RECOVERY FROM TRANSIENT CEREBRAL-ISCHEMIA IN RAT-BRAIN - TISSUE-LEVELS OF ACETYLCHOLINE, MONOAMINES, AND THEIR METABOLITES [J].

FROLICH, L ;

DIRR, A ;

RIEDERER, P ;

HOYER, S .

NEUROCHEMICAL RESEARCH, 1993, 18 (12) :1239-1244

[4]

DETERMINATION OF ACETYLCHOLINE AND CHOLINE IN PERCHLORATE EXTRACTS OF BRAIN-TISSUE USING LIQUID-CHROMATOGRAPHY ELECTROCHEMISTRY WITH AN IMMOBILIZED-ENZYME REACTOR [J].

FUJIMORI, K ;

YAMAMOTO, K .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 414 (01) :167-173

[5]

STUDIES ON ATTENUATION OF POSTISCHEMIC BRAIN INJURY BY KAMPO MEDICINES-INHIBITORY EFFECTS OF FREE-RADICAL PRODUCTION .1. [J].

FUSHITANI, S ;

TSUCHIYA, K ;

MINAKUCHI, K ;

TAKASUGI, M ;

MURAKAMI, K .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1994, 114 (06) :388-394

[6]

ALTERATIONS IN ACETYLCHOLINE SYNTHESIS AND CYCLIC NUCLEOTIDES IN MILD CEREBRAL HYPOXIA [J].

GIBSON, GE ;

SHIMADA, M ;

BLASS, JP .

JOURNAL OF NEUROCHEMISTRY, 1978, 31 (04) :757-760

[7]

IMPAIRED SYNTHESIS OF ACETYLCHOLINE BY MILD HYPOXIC HYPOXIA OR NITROUS-OXIDE [J].

GIBSON, GE ;

DUFFY, TE .

JOURNAL OF NEUROCHEMISTRY, 1981, 36 (01) :28-33

[8]

REGIONAL STUDIES OF CATECHOLAMINES IN RAT BRAIN .I. DISPOSITION OF [3H]NOREPINEPHRINE [3H]DOPAMINE AND [3H]DOPA IN VARIOUS REGIONS OF BRAIN [J].

GLOWINSKI, J ;

IVERSEN, LL .

JOURNAL OF NEUROCHEMISTRY, 1966, 13 (08) :655-+

[9]

THE EFFECTS OF SHO-SAIKO-TO-GO-KEISHI-KA-SHAKUYAKU-TO (TJ-960) ON ISCHEMIA-INDUCED CHANGES OF BRAIN ACETYLCHOLINE AND MONOAMINE LEVELS IN GERBILS [J].

HABA, K ;

OGAWA, N ;

MORI, A .

NEUROCHEMICAL RESEARCH, 1990, 15 (05) :487-493

[10]

TIME COURSE OF CHANGES IN LIPID-PEROXIDATION, PRESYNAPTIC AND POSTSYNAPTIC CHOLINERGIC INDEXES, NMDA RECEPTOR-BINDING AND NEURONAL DEATH IN THE GERBIL HIPPOCAMPUS FOLLOWING TRANSIENT ISCHEMIA [J].

HABA, K ;

OGAWA, N ;

MIZUKAWA, K ;

MORI, A .

BRAIN RESEARCH, 1991, 540 (1-2) :116-122