Calcium and retinal function

被引：31

作者：

Akopian, A

Witkovsky, P

机构：

[1] NYU, Sch Med, Med Ctr, Dept Ophthalmol, New York, NY 10016 USA

[2] NYU, Sch Med, Med Ctr, Dept Physiol & Neurosci, New York, NY 10016 USA

来源：

MOLECULAR NEUROBIOLOGY | 2002年 / 25卷 / 02期

关键词：

calcium; retina; phototransduction; ganglion cell; calmodulin; glutamate; metabotropic glutamate receptor; GABA;

D O I：

10.1385/MN:25:2:113

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We survey the primary roles of calcium in retinal function, including photoreceptor transduction, transmitter release by different classes of retinal neuron, calcium-mediated regulation of gap-junctional conductance, activation of certain voltage-gated channels for K+ and Cl-, and modulation of postsynaptic potentials in retinal ganglion cells. We discuss three mechanisms for changing [Ca2+](i), which include flux through voltage-gated calcium channels, through ligand-gated channels, and by release from stores. The neuromodulatory pathways affecting each of these routes of entry are considered. The many neuromodulatory mechanisms in which calcium is a player are described and their effects upon retinal function discussed.

引用

收藏

页码：113 / 132

页数：20

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