Manipulating cellular transport and immune responses:: dynamic interactions between intracellular Salmonella enterica and its host cells

被引：117

作者：

Abrahams, GL ^{[1
]}

Hensel, M ^{[1
]}

机构：

[1] FAU Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, Erlangen, Germany

来源：

CELLULAR MICROBIOLOGY | 2006年 / 8卷 / 05期

关键词：

D O I：

10.1111/j.1462-5822.2006.00706.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intracellular survival and replication within eukaryotic host cells is of central importance for the pathogenesis of infections caused by Salmonella enterica. Intracellular Salmonella translocates a set of effector proteins by means of a type III secretion system (T3SS) encoded by Salmonella pathogenicity island 2 (SPI2) that manipulates normal host-cell functions. Intracellular survival and replication is linked to the function of the SPI2-T3SS, but recent observations show that many additional cellular functions are targeted by this virulence system. In this review, we focus on the recent observations on the interference of intracellular Salmonella with functions of the innate and adaptive immune system and the modification of endocytic and exocytic cellular transport. The common molecular basis of the different SPI2-dependent phenotypes could be the interference with cellular transport along microtubules.

引用

页码：728 / 737

页数：10

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