Hybrid Multicomponent Hydrogels for Tissue Engineering

被引:215
作者
Jia, Xinqiao [1 ]
Kiick, Kristi L. [1 ]
机构
[1] Univ Delaware, Dept Mat Sci & Engn, Delaware Biotechnol Inst, Newark, DE 19716 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
drug delivery; extracellular matrix; heparin; hyaluronic acid; hybrid hydrogels; microgels; networks; polysaccharide particles; tissue engineering; ENDOTHELIAL GROWTH-FACTOR; HYALURONIC-ACID; EXTRACELLULAR-MATRIX; DRUG-DELIVERY; IN-VITRO; NANOCOMPOSITE HYDROGELS; CONTROLLED-RELEASE; CELL-ADHESION; BIODEGRADABLE HYDROGELS; MECHANICAL-PROPERTIES;
D O I
10.1002/mabi.200800284
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrating modular and heterogeneous building blocks into well-defined, multifunctional hydrogel composites. The individual building blocks can be chemically, morphologically, and functionally diverse, and the hybridization can occur at molecular level or microscopic scale. The modular nature of the designs, combined with the potential synergistic effects of the hybrid systems, has resulted in novel hydrogel matrices with robust structure and defined functions.
引用
收藏
页码:140 / 156
页数:17
相关论文
共 199 条
[1]   ELASTIN AS A RANDOM-NETWORK ELASTOMER - A MECHANICAL AND OPTICAL ANALYSIS OF SINGLE ELASTIN FIBERS [J].
AARON, BB ;
GOSLINE, JM .
BIOPOLYMERS, 1981, 20 (06) :1247-1260
[2]   Collagens -: major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair [J].
Aigner, T ;
Stöve, J .
ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (12) :1569-1593
[3]  
Alberts B., 2007, Molecular Biology of the Cell. (4th edition), Vfifth
[4]   Materials science - Smart biomaterials [J].
Anderson, DG ;
Burdick, JA ;
Langer, R .
SCIENCE, 2004, 305 (5692) :1923-1924
[5]  
[Anonymous], 2008, COLLAGEN STRUCTURE M
[6]   Structure and biological activity of the extracellular matrix [J].
Aumailley, M ;
Gayraud, B .
JOURNAL OF MOLECULAR MEDICINE-JMM, 1998, 76 (3-4) :253-265
[7]  
BELLINGHAM CM, 2003, BIOMATERIALS, V70, P44
[8]   Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation [J].
Benoit, DSW ;
Anseth, KS .
ACTA BIOMATERIALIA, 2005, 1 (04) :461-470
[9]   Controlled drug delivery in tissue engineering [J].
Biondi, Marco ;
Ungaro, Francesca ;
Quaglia, Fabiana ;
Netti, Paolo Antonio .
ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (02) :229-242
[10]  
Birk D.E., 1994, EXTRACELLULAR MATRIX