Mechanobiology in the third dimension

被引:293
作者
Pedersen, JA
Swartz, MA [1 ]
机构
[1] Swiss Fed Inst Technol, Lab Mechanobiol & morphogenesis, Integrat Biosci Inst, EPFL,Stn 15, CH-1015 Lausanne, Switzerland
[2] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
关键词
cell mechanics; tissue mechanics; collagen; fibrin; tissue engineering; hydrogel; fibroblast; stress shielding; cell strain;
D O I
10.1007/s10439-005-8159-4
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Cells are mechanically coupled to their extracellular environments, which play critical roles in both communicating the state of the mechanical environment to the cell as well as in mediating cellular response to a variety of stimuli. Along with the molecular composition and mechanical properties of the extracellular matrix (ECM), recent work has demonstrated the importance of dimensionality in cell-ECM associations for controlling the sensitive communication between cells and the ECM. Matrix forces are generally transmitted to cells differently when the cells are on two-dimensional (2D) vs. within three-dimensional (3D) matrices, and cells in 3D environments may experience mechanical signaling that is unique vis-a-vis cells in 2D environments, such as the recently described 3D-matrix adhesion assemblies. This review examines how the dimensionality of the extracellular environment can affect in vitro cell mechanobiology, focusing on collagen and fibrin systems.
引用
收藏
页码:1469 / 1490
页数:22
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