A new Notch in the HIF belt: How hypoxia impacts differentiation

被引：26

作者：

Cejudo-Martin, P ^{[1
]}

Johnson, RS ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, Mol Biol Sect, La Jolla, CA 92093 USA

来源：

DEVELOPMENTAL CELL | 2005年 / 9卷 / 05期

关键词：

D O I：

10.1016/j.devcel.2005.10.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the current issue of Developmental Cell, work by Gustafsson and coworkers demonstrates that hypoxia synergizes with Notch to inhibit differentiation of myogenic and neural precursor cells (Gustafsson et al., 2005). This effect requires a newly described interaction between the transcriptionally active form of HIF-1 alpha and the intracellular domain of Notch.

引用

页码：575 / 576

页数：2

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