Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis

被引：72

作者：

Frigerio, Francesca ^{[1
]}

Casimir, Marina ^{[1
]}

Carobbio, Stefania ^{[1
]}

Maechler, Pierre ^{[1
]}

机构：

[1] Univ Geneva, Med Ctr, Dept Cell Physiol & Metab, CH-1211 Geneva, Switzerland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2008年 / 1777卷 / 7-8期

关键词：

glutamate; mitochondria; glutamate dehydrogenase; glutamate carrier; pancreatic beta-cell; SIRT;

D O I：

10.1016/j.bbabio.2008.04.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Glutamate is implicated in numerous metabolic and signalling functions that vary according to specific tissues. Glutamate metabolism is tightly controlled by activities of mitochondrial enzymes and transmembrane carriers, in particular glutamate dehydrogenase and mitochondrial glutamate carriers that have been identified in recent years. It is remarkable that, although glutamate-specific enzymes and transporters share similar properties in most tissues, their regulation varies greatly according to particular organs in order to achieve tissue specific functions. This is illustrated in this review when comparing glutamate handling in liver, brain, and pancreatic beta-cells. We describe the main cellular glutamate pathways and their specific functions in different tissues, ultimately contributing to the control of metabolic homeostasis at the organism level. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：965 / 972

页数：8

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