Curcumin and Inflammatory Bowel Disease: Biological Mechanisms and Clinical Implication

被引:53
作者
Ali, Tauseef [1 ,2 ,3 ]
Shakir, Faiz [1 ]
Morton, Jordan [2 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Sect Digest Dis & Nutr, Oklahoma City, OK 73104 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Oklahoma City, OK 73104 USA
[3] VA Med Ctr, Oklahoma City, OK USA
关键词
Curcumin; Turmeric; Inflammatory bowel disease; Herbal therapy; NF-KAPPA-B; OPTIMAL SEARCH STRATEGIES; DIETARY CURCUMIN; INDUCED COLITIS; DOWN-REGULATION; FATTY-ACIDS; THERAPY; EXPRESSION; ANTIOXIDANT; MODULATION;
D O I
10.1159/000336720
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Increased recognition of the limits of conventional medicine has helped drive the growing interest in complementary and alternative medicine which is now being commonly used in patients with chronic diseases, including individuals with Crohn's disease and ulcerative colitis. Recently, scientific interest has unraveled the beneficial pharmacological effects of curcumin. We present an updated concise review of currently available in vitro, animal and clinical studies demonstrating the therapeutic effect of herbal medication in inflammatory bowel disease. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码:249 / 255
页数:7
相关论文
共 57 条
[1]
Safety Profile of IBD Therapeutics: Infectious Risks (Reprinted from Gastroenterology Clinics of North America, vol 38) [J].
Afif, Waqqas ;
Loftus, Edward V., Jr. .
MEDICAL CLINICS OF NORTH AMERICA, 2010, 94 (01) :115-+
[2]
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases [J].
Aggarwal, Bharat B. ;
Harikumar, Kuzhuvelil B. .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (01) :40-59
[3]
Barnes PM, 2008, 12 CDC NAT CTR HLTH
[4]
Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study [J].
Beaugerie, Laurent ;
Brousse, Nicole ;
Bouvier, Anne Marie ;
Colombel, Jean Frederic ;
Lemann, Marc ;
Cosnes, Jacques ;
Hebuterne, Xavier ;
Cortot, Antoine ;
Bouhnik, Yoram ;
Gendre, Jean Pierre ;
Simon, Tabassome ;
Maynadie, Marc ;
Hermine, Olivier ;
Faivre, Jean ;
Carrat, Fabrice .
LANCET, 2009, 374 (9701) :1617-1625
[5]
Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells [J].
Bhaumik, S ;
Jyothi, MD ;
Khar, A .
FEBS LETTERS, 2000, 483 (01) :78-82
[6]
Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent [J].
Billerey-Larmonier, Claire ;
Uno, Jennifer K. ;
Larmonier, Nicolas ;
Midura, Anna J. ;
Timmermann, Barbara ;
Ghishan, Fayez K. ;
Kiela, Pawel R. .
INFLAMMATORY BOWEL DISEASES, 2008, 14 (06) :780-793
[7]
Connecting the dots from Toll-like receptors to innate immune cells and inflammatory bowel disease [J].
Boone, DL ;
Ma, A .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (09) :1284-1286
[8]
Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and NOS expression in chronic experimental colitis [J].
Camacho-Barquero, Laura ;
Villegas, Isabel ;
Sanchez-Calvo, Juan Manuel ;
Talero, Elena ;
Sanchez-Fidalgo, Susana ;
Motilva, Virginia ;
de la Lastra, Catalina Alarcon .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2007, 7 (03) :333-342
[9]
Cheng AL, 2001, ANTICANCER RES, V21, P2895
[10]
Cuendet M, 2000, Drug Metabol Drug Interact, V17, P109