CD14

被引：68

作者：

Schütt, C ^{[1
]}

机构：

[1] Univ Greifswald, Inst Immunol & Transfus Med, D-17487 Greifswald, Germany

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1999年 / 31卷 / 05期

关键词：

endotoxin receptor; innate immunity; sepsis;

D O I：

10.1016/S1357-2725(98)00153-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide. intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses. Since the CD14 molecule does not have a membrane spanning domain it cannot transmit a signal into the cell. Some as yet unidentified accessory protein is thought to be involved. It will be important to clarify the signalling systems involved since they may provide a therapeutic target for sepsis intervention strategies. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：545 / 549

页数：5

共 15 条

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