Antitumor and immunomodulating activity of a polysaccharide from Sophora flavescens Ait.

被引：61

作者：

Bai, Lu ^{[1
]}

Zhu, Li-Ying ^{[2
]}

Yang, Bao-Shan ^{[3
]}

Shi, Li-Jun ^{[4
]}

Liu, Yong ^{[1
]}

Jiang, Ai-Min ^{[1
]}

Zhao, Li-Li ^{[1
]}

Song, Guang ^{[1
]}

Liu, Tie-Fu ^{[1
]}

机构：

[1] Harbin Med Univ, Hosp 4, Dept Gastroenterol, Harbin 150001, Peoples R China

[2] Harbin Med Univ, Hosp 4, Infect Dept, Harbin 150001, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 2, Infect Dept, Harbin 150001, Peoples R China

[4] Harbin Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Harbin 150001, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 05期

关键词：

Sophora flavescens; Polysaccharide; Immunomodulation; Antitumor; Macrophage; ROOTS;

D O I：

10.1016/j.ijbiomac.2012.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The immunostimulatory activity of Sophora flavescens polysaccharide (SFPW1) was evaluated by using in vitro cell models and in vivo animal models. The results demonstrated that SFPW1 could effectively inhibit the tumor growth in H22 tumor-bearing mice and promote the splenocyte proliferation, thus resulting in a prolonged life survival. For assay in vitro, SFPW1 significantly strengthened peritoneal macrophages to devour H22 tumor cells and stimulated macrophages to produce nitric oxide (NO) via up-regulation of inducible NO synthase (iNOS) activity. However, no direct cytotoxicity against H22 tumor cells was observed in vitro. These results suggest that SFPW1 might be a strong natural immunomodulator and the antitumor effect of this polysaccharide is associated with its potent immunostimulating effect. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：705 / 709

页数：5

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