NEURAL PRECURSOR CELL LINES PROMOTE NEURITE BRANCHING

被引：11

作者：

Neville, Craig M. ^{[1
]}

Huang, Albert Y. ^{[1
]}

Shyu, Jeffrey Y. ^{[1
]}

Snyder, Evan Y. ^{[3
]}

Hadlock, Tessa A. ^{[2
]}

Sundback, Cathryn A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA

[3] Burnham Inst, La Jolla, CA 92037 USA

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2009年 / 119卷 / 01期

关键词：

dorsal root ganglia; neural progenitor cells; neuroma; peripheral nerve regeneration; rat sciatic nerve; Schwann cells; PERIPHERAL-NERVE REGENERATION; ADULT SENSORY NEURONS; GROWTH-FACTOR-I; ROOT GANGLION NEURONS; MARROW STROMAL CELLS; SPINAL-CORD-INJURY; RAT SCIATIC-NERVE; STEM-CELLS; SCHWANN-CELLS; NEUROTROPHIC FACTOR;

D O I：

10.1080/00207450802480218

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Schwann cells and primary progenitor cells improve regeneration across peripheral nerve defects. This study examined the impact of immortalized neural precursor cells on regeneration of rat nerve defects. Across 10-mm gaps, neuromas formed without neural cables with C17.2- or RN33B-transplanted cells, but neural cables formed across 5-mm gaps seeded with RN33B cells. In vitro, dorsal root ganglia neurites elongated across Schwann and RN33B cells; RN33B cells induced neurite branching with shorter total outgrowth. Neural cable formation in vivo was likely determined by the balance of guidance and branch-inducing factors secreted by Schwann and transplanted precursor cells.

引用

页码：15 / 39

页数：25

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