Functions of the fragile X protein

被引：10

作者：

Oostra, BA ^{[1
]}

机构：

[1] Erasmus Univ, CBG Dept Clin Genet, NL-3000 DR Rotterdam, Netherlands

来源：

TRENDS IN MOLECULAR MEDICINE | 2002年 / 8卷 / 03期

关键词：

D O I：

10.1016/S1471-4914(02)02271-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fragile X syndrome is caused by the absence of the FMR1 protein (FMRP). FMRP is an RNA-binding protein that can bind 4% of mRNA species. Several of those mRNAs have now been identified. FMRP binds to its own mRNA to a sequence containing a G quartet structure -a structure also found in some of the other mRNAs. This interesting new finding, which has used clues from a Drosophila fragile X model, are discussed here.

引用

页码：102 / 103

页数：2

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