Valproic acid adjunctive therapy for HIV-associated cognitive impairment: A first report

被引：67

作者：

Schifitto, G

Peterson, DR

Zhong, J

Ni, H

Cruttenden, K

Gaugh, M

Gendelman, HE

Boska, M

Gelbard, H

机构：

[1] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA

[2] Univ Rochester, Med Ctr, Dept Biostat, Rochester, NY 14642 USA

[3] Univ Rochester, Med Ctr, Dept Radiol, Rochester, NY 14642 USA

[4] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA

[5] Univ Nebraska, Med Ctr, Dept Radiol, Omaha, NE 68105 USA

来源：

NEUROLOGY | 2006年 / 66卷 / 06期

关键词：

D O I：

10.1212/01.wnl.0000204294.28189.03

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In vitro and animal model data demonstrate that valproic acid (VPA) can ameliorate HIV-associated neurotoxicity. The authors conducted a pilot 10-week placebo-controlled study of VPA 250 mg twice daily in 22 HIV-infected individuals with (n = 16) and without (n = 6) cognitive impairment. VPA was safe and well tolerated, with trends toward improved neuropsychological performance and brain metabolism in the impaired subjects.

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收藏

页码：919 / 921

页数：3

相关论文

共 10 条

[1] Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia [J].

Chang, L ;

Ernst, T ;

Leonido-Yee, M ;

Witt, M ;

Speck, O ;

Walot, I ;

Miller, EN .

NEUROLOGY, 1999, 53 (04) :782-789

[2] Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults [J].

DiCenzo, R ;

Peterson, D ;

Cruttenden, M ;

Morse, G ;

Riggs, G ;

Gelbard, H ;

Schifitto, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (11) :4328-4331

[3]

Dou HY, 2003, J NEUROSCI, V23, P9162

[4] THE FATIGUE SEVERITY SCALE - APPLICATION TO PATIENTS WITH MULTIPLE-SCLEROSIS AND SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

KRUPP, LB ;

LAROCCA, NG ;

MUIRNASH, J ;

STEINBERG, AD .

ARCHIVES OF NEUROLOGY, 1989, 46 (10) :1121-1123

[5] Depletion of latent HIV-1 infection in vivo: a proof-of-concept study [J].

Lehrman, G ;

Hogue, IB ;

Palmer, S ;

Jennings, C ;

Spina, CA ;

Wiegand, A ;

Landay, AL ;

Coombs, RW ;

Richman, DD ;

Mellors, JW ;

Coffin, JM ;

Bosch, RJ ;

Margolis, DM .

LANCET, 2005, 366 (9485) :549-555

[6]

Marder K, 1996, NEUROLOGY, V47, P1247

[7] REDUCED BRAIN N-ACETYLASPARTATE SUGGESTS NEURONAL LOSS IN COGNITIVELY IMPAIRED HUMAN-IMMUNODEFICIENCY-VIRUS-SEROPOSITIVE INDIVIDUALS - INVIVO H-1 MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING [J].

MEYERHOFF, DJ ;

MACKAY, S ;

BACHMAN, L ;

POOLE, N ;

DILLON, WP ;

WEINER, MW ;

FEIN, G .

NEUROLOGY, 1993, 43 (03) :509-515

[8] Sodium valproate, an anticonvulsant drug, stimulates human immunodeficiency virus type 1 replication independently of glutathione levels [J].

Moog, C ;

KuntzSimon, G ;

CaussinSchwemling, C ;

Obert, G .

JOURNAL OF GENERAL VIROLOGY, 1996, 77 :1993-1999

[9] Clinical and spectroscopic improvement in HIV-associated cognitive impairment [J].

Stankoff, B ;

Tourbah, A ;

Suarez, S ;

Turell, E ;

Stievenart, JL ;

Payan, C ;

Coutellier, A ;

Herson, S ;

Baril, L ;

Bricaire, F ;

Calvez, V ;

Cabanis, EA ;

Lacomblez, L ;

Lubetzki, C .

NEUROLOGY, 2001, 56 (01) :112-115

[10] Activation of glycogen synthase kinase 3 beta (GSK-3β) by platelet activating factor mediates migration and cell death in cerebellar granule neurons [J].

Tong, N ;

Sanchez, JF ;

Maggirwar, SB ;

Ramirez, SH ;

Guo, H ;

Dewhurst, S ;

Gelbard, HA .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (10) :1913-1922