Hsp90 as an anti-cancer target

被引：64

作者：

Neckers, L ^{[1
]}

Mimnaugh, E ^{[1
]}

Schulte, TW ^{[1
]}

机构：

[1] NCI, Med Branch, Dept Cell & Canc Biol, NIH, Rockville, MD 20850 USA

来源：

DRUG RESISTANCE UPDATES | 1999年 / 2卷 / 03期

关键词：

D O I：

10.1054/drup.1999.0082

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Heat shock protein 90 is one of the most abundant cellular proteins. Although its functions are still being characterized, it appears to serve as a chaperone for a growing list of cell signaling proteins, including many tyrosine and serine/threonine kinases, involved in cell proliferation and/or survival. The recent discovery of natural products which are able to inhibit Hsp90 function have allowed for both identification of its client proteins and for a better understanding of its role in their activity. Accumulating data have suggested that targeting Hsp90 in cancer cells may be of clinical benefit.

引用

页码：165 / 172

页数：8

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