Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats

被引:107
作者
Hashimoto, S
Inoue, T
Koyama, T
机构
[1] Department of Psychiatry, Hokkaidko University, School of Medicine, Kita-ku, Sapporo 060
关键词
anxiety; conditioned fear stress; freezing behavior; serotonin reuptake inhibitors; citalopram; fluvoxamine; milnacipran;
D O I
10.1007/BF02246175
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety. In the present study, freezing was used to determine the anxiolytic activity of selective serotonin reuptake inhibitors (SSRIs), which are reported to be clinically effective in anxiety disorders. The duration of freezing behavior was reduced by acute treatment with the SSRIs citalopram (1-10 mg/kg) and fluvoxamine (3-30 mg/kg). Acute treatment with the serotonin (5-HT) /noradrenaline (NA) mixed reuptake inhibitor milnacipran (3-30 mg/kg) also attenuated CFS-induced freezing, while acute treatment with the NA reuptake inhibitors maprotiline and ORG4428, and the dopamine (DA) reuptake inhibitor GBR12909 failed to alter CFS-induced freezing. These results indicate that facilitation of 5-HT availability in the brain produced by 5-HT reuptake inhibition reduces CFS-induced freezing behavior. CFS may be a useful model for detecting the anxiolytic potential of 5-HT reuptake inhibitors.
引用
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页码:182 / 186
页数:5
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