Heterozygous familial hypercholesterolemia in Spain.: Description of 819 non related cases

被引:26
作者
Alonso, R
Castillo, S
Civeira, F
Puzo, J
de la Cruz, JJ
Pocoví, M
Mata, P
机构
[1] Fdn Jimenez Diaz, Med Interna Serv, Unidad Lipidos, E-28040 Madrid, Spain
[2] Univ Zaragoza, Dept Bioquim & Biol Mol & Celular, Zaragoza, Spain
[3] Hosp Univ Miguel Servet, Med Interna Serv, Zaragoza, Spain
[4] Hosp Gen San Jorge, Lab Bioquim, Huesca, Spain
[5] Univ Autonoma Madrid, Dept Med Prevent & Salud Publ, E-28049 Madrid, Spain
来源
MEDICINA CLINICA | 2002年 / 118卷 / 13期
关键词
heterozygous familial hypercholesterolemia; cardiovascular disease; xanthomas; risk factors;
D O I
10.1016/S0025-7753(02)72428-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Heterozygous familial hypercholesterolemia (hFH) is an inherited disorder commonly found among the general population. Premature cardiovascular disease, especially coronary artery disease, is the most important complication in these patients. The aim of this study was to analyze the clinical manifestations and the characteristics of cardiovascular disease in the Spanish hFH population. Patients and method; Analysis of 819 non-related cases (449 females and 370 males), with a clinical diagnosis of familial hypercholesterolemia, from 69 lipid clinics. Clinical and lipid profile at diagnosis along with personal and familial backgrounds related to cardiovascular disease were registered in a central database. Results: Mean total cholesterol at diagnosis was 412 (87) mg/dl in women, and 400 (78) mg/dl in men (p=0.049). HDL-c was higher in females than in males (57 [14] vs. 47.7 [12.7] mg/dl, respectively, p<0.0001). Xantomas were present in 22.5% of cases, and 21.7% of subjects had evidence of premature cardiovascular disease which was more frequent in males than in females (30.8% and 14.3%, respectively; p<0.001). In a multivariant analysis, a significant and positive correlation was observed between cardiovascular disease and age, gender, tobacco consumption, LDL-c levels, blood pressure and body mass index. Conclusions: The clinical manifestations and the presence of cardiovascular disease in Spanish hFH patients are similar to those described in other populations. LDL-c levels, age, gender, smoking, hypertension and body mass index are important predictors of cardiovascular disease in these patients.
引用
收藏
页码:487 / 492
页数:6
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