Nanoparticle-assisted visualization of binding interactions between collagen mimetic peptide and collagen fibers

被引：73

作者：

Mo, X

An, YJ

Yun, CS

Yu, SM

机构：

[1] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 14期

关键词：

fibrous proteins; gold; helical structures; nanostructures; peptides;

D O I：

10.1002/anie.200504529

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Collagen treatment: Gold nanoparticles conjugated with collagen mimetic peptide (CMP) form stable adducts with collagen fibers (see picture) that are visible by transmission electron microscopy, thereby allowing the study of binding interactions between CMPs and type I collagen fibers. This labeling technique may potentially be used to identify structural abnormalities in collagen fibers that are related to diseases. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：2267 / 2270

页数：4

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