The bromodomain: a chromatin-targeting module?

被引：221

作者：

Winston, F ^{[1
]}

Allis, CD

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Univ Virginia, Ctr Hlth Sci, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1999年 / 6卷 / 07期

关键词：

D O I：

10.1038/10640

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has recently been demonstrated that bromodomains - motifs found in several eukaryotic transcription factors - bind to acetyl-lysine, a modification of histones that is important for transcription. This finding suggests that the regulatory effects of histone acetylation may be exerted by bromodomain-containing proteins.

引用

页码：601 / 604

页数：4

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