The L-AP4 receptor

被引:35
作者
Thomsen, C
机构
[1] Novo Nordisk A/S, Department of Molecular Pharmacology, Novo Nordisk Park
来源
GENERAL PHARMACOLOGY | 1997年 / 29卷 / 02期
关键词
presynaptic receptor; lateral perforant path; calcium/chloride-dependent glutamate uptake; receptor autoradiography; H-3]-L-AP4 binding; (1S; 3R)-ACPD; phenylglycine derivatives; priming effect;
D O I
10.1016/S0306-3623(96)00417-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The L-2-amino-4-phosphonobutyric acid (L-AP4) receptor was originally discovered by the ability of L-AP4 to depress synaptic transmission in hippocampal glutamatergic pathways and in the retina. 2. The molecular identity of the L-AP4 receptor is not yet resolved; however, with the molecular cloning of subtypes of metabotropic glutamate receptors (mGluRs), high affinity targets for L-AP4 have been identified. 3. As the information on the pharmacology of the mGluRs and the electrophysiological and biochemical studies on L-AP4 receptor physiology becomes elaborated it seems evident that the L-AP4 receptor is not a single molecular target but may involve multiple receptor subtypes. GEN PHARMAC 29;2:151-158, 1997. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:151 / 158
页数:8
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