Infection of primary cultures of human Kupffer cells by dengue virus: No viral progeny synthesis, but cytokine production is evident

被引：85

作者：

Marianneau, P

Steffan, AM

Royer, C

Drouet, MT

Jaeck, D

Kirn, A

Deubel, V

机构：

[1] Inst Pasteur, Unite Arbovirus & Virus Fievres Hemorrag, F-75724 Paris 15, France

[2] CHU Hautepierre, INSERM U74, Fac Med, Virol Lab, F-67000 Strasbourg, France

[3] CHU Hautepierre, Ctr Chirurg Viscerale & Transplantation, F-67000 Strasbourg, France

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 06期

关键词：

D O I：

10.1128/JVI.73.6.5201-5206.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the ability of dengue virus to invade human primary Kupffer cells and to complete its life cycle. The virus effectively penetrated Kupffer cells, but the infection did not result in any viral progeny. Dengue virus-replicating Kupffer cells underwent apoptosis and were cleared by phagocytosis. Infected Kupffer cells produced soluble mediators that could intervene in dengue virus pathogenesis.

引用

页码：5201 / 5206

页数：6

共 29 条

[1] PATHOLOGY OF THAILAND HAEMORRHAGIC FEVER - A STUDY OF 100 AUTOPSY CASES [J].