Synergistic methodologies for the synthesis of 3-aroyl-2-arylbenzo[b]thiophene-based selective estrogen receptor modulators.: Two concise syntheses of raloxifene

被引：33

作者：

Bradley, DA ^{[1
]}

Godfrey, AG ^{[1
]}

Schmid, CR ^{[1
]}

机构：

[1] Lilly Corp Ctr, Lilly Res Labs, Eli Lilly & Co Div A, Indianapolis, IN 46285 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(99)00955-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Difunctionalized benzo[b] thiophene intermediates are prepared which allow fully independent elaboration of the 2-aryl position or the tether position of benzo[b]thiophene-based selective estrogen receptor modulators (SERMs). Two concise syntheses of the SERM raloxifene (Evista(R)) are presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5155 / 5159

页数：5

共 31 条

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