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The developmental origins of adipose tissue

被引：284
作者：
Berry, Daniel C. [1 ]
Stenesen, Drew [1 ]
Zeve, Daniel [1 ]
Graff, Jonathan M. [1 ,2 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA
来源：
DEVELOPMENT | 2013年 / 140卷 / 19期
基金：
美国国家卫生研究院;
关键词：
Adipose; Adipocyte; Development; Stem cells; Niche; Vascular niche; BODY-FAT DISTRIBUTION; ADIPOCYTE DIFFERENTIATION; PPAR-GAMMA; STEM-CELLS; IN-VIVO; TRANSCRIPTIONAL CONTROL; INSULIN-RESISTANCE; OBESITY; WHITE; ADIPOGENESIS;
D O I：
10.1242/dev.080549
中图分类号：
Q [生物科学];
学科分类号：
090105 [作物生产系统与生态工程];
摘要：
Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms. Once formed, the tissue is dynamic, responding to homeostatic and external cues and capable of a 15-fold expansion. The formation and maintenance of adipose tissue is essential to many biological processes and when perturbed leads to significant diseases. Despite this basic and clinical significance, understanding of the developmental biology of adipose tissue has languished. In this Review, we highlight recent efforts to unveil adipose developmental cues, adipose stem cell biology and the regulators of adipose tissue homeostasis and dynamism.
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收藏
页码：3939 / 3949
页数：11
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