Clinical outcomes of patients with low-flow, low-gradient, severe aortic stenosis and either preserved or reduced ejection fraction undergoing transcatheter aortic valve implantation

Our aim was to evaluate the invasive haemodynamic indices of high-risk symptomatic patients presenting with paradoxical low-flow, low-gradient, severe aortic stenosis (AS) (PLF-LG) and low-flow, low-gradient severe AS (LEF-LG) and to compare clinical outcomes following transcatheter aortic valve implantation (TAVI) among these challenging AS subgroups. Of 534 symptomatic patients undergoing TAVI, 385 had a full pre-procedural right and left heart catheterization. A total of 208 patients had high-gradient severe AS [HGAS; mean gradient (MG) 40 mmHg], 85 had PLF-LG [MG 40 mmHg, indexed aortic valve area [iAVA] 0.6 cm(2) m(2), stroke volume index 35 mL/m(2), ejection fraction (EF) 50], and 61 had LEF-LG (MG 40 mmHg, iAVA 0.6 cm(2) m(2), EF 40). Compared with HGAS, PLF-LG and LEF-LG had higher systemic vascular resistances (HGAS: 1912 654 vs. PLF-LG: 2006 586 vs. LEF-LG: 2216 765 dyne s m(5), P 0.007) but lower valvulo-arterial impedances (HGAS: 7.8 2.7 vs. PLF-LG: 6.9 1.9 vs. LEF-LG: 7.7 2.5 mmHg mL(1) m(2), P 0.027). At 30 days, no differences in cardiac death (6.5 vs. 4.9 vs. 6.6, P 0.90) or death (8.4 vs. 6.1 vs. 6.6, P 0.88) were observed among HGAS, PLF-LG, and LEF-LG groups, respectively. At 1 year, New York Heart Association functional improvement occurred in most surviving patients (HGAS: 69.2 vs. PLF-LG: 71.7 vs. LEF-LG: 89.3, P 0.09) and no significant differences in overall mortality were observed (17.6 vs. 20.5 vs. 24.5, P 0.67). Compared with HGAS, LEF-LG had a higher 1 year cardiac mortality (adjusted hazard ratio 2.45, 95 confidence interval 1.045.75, P 0.04). TAVI in PLF-LG or LEF-LG patients is associated with overall mortality rates comparable with HGAS patients and all groups profit symptomatically to a similar extent.