3-O-Substituted benzyl pyridazinone derivatives as COX inhibitors

被引：66

作者：

Chintakunta, VK

Akella, V

Vedula, MS

Mamnoor, PK

Mishra, P

Casturi, SR

Vangoori, A

Rajagopalan, R

机构：

[1] Dr Reddys Res Fdn, Discovery Chem, Hyderabad 500050, Andhra Pradesh, India

[2] Dr Reddys Res Fdn, Discovery Biol, Hyderabad 500050, Andhra Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 37卷 / 04期

关键词：

3-O-substituted benzyl pyridazinone; COX inhibitors; anti-inflammatory activity;

D O I：

10.1016/S0223-5234(02)01336-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

New 3-O-substituted benzyl pyridazinone compounds have been synthesised and evaluated for their cyclooxygenase inhibitor,, activity and COX-2 selectivity. Among the compounds synthesised. three compounds (11b-11d) have shown in vitro COX-2 selectivity. These Compounds have been evaluated for their in vivo potential using carrageenan-induced rat paw edema assay. One compound (11b) showed 32% anti-inflammatory activity at 30 mg k(-1) dose. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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收藏

页码：339 / 347

页数：9

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