What do I need to know about immunoglobulin light chain (AL) amyloidosis?

被引：100

作者：

Dispenzieri, Angela ^{[1
]}

Gertz, Morie A. ^{[1
]}

Buadi, Francis ^{[1
]}

机构：

[1] Mayo Clin, Rochester, MN 55905 USA

来源：

BLOOD REVIEWS | 2012年 / 26卷 / 04期

关键词：

Amyloidosis; Multisystem disease; Monoclonal gammopathy; Prognosis; Transplantation; PRIMARY SYSTEMIC AMYLOIDOSIS; STEM-CELL TRANSPLANTATION; HIGH-DOSE MELPHALAN; BRAIN NATRIURETIC PEPTIDE; TWICE-WEEKLY BORTEZOMIB; CLONAL PLASMA-CELLS; CARDIAC AMYLOIDOSIS; HEART-TRANSPLANTATION; INTRAVENOUS MELPHALAN; LOCALIZED AMYLOIDOSIS;

D O I：

10.1016/j.blre.2012.03.001

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Immunoglobulin light chain (AL) amyloidosis is the most common acquired systemic amyloidoses. Its presentation is often insidious and progressive, which may delay diagnosis. The interval between first symptoms and actual diagnosis along the intrinsic heterogeneity of tissue tropism create a wide spectrum of presentations, both in terms of scope and depth of symptoms and signs and functional status of patients. In this review, the authors review the pathogenesis, diagnosis and differential diagnosis of AL amyloidosis along with the prognosis and state-of-the-art management for patients with this affliction. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：137 / 154

页数：18

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