Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: Implication for assessment of disease activity and treatment

被引：60

作者：

Mazzanti, Benedetta ^{[2
]}

Aldinucci, Alessandra ^{[1
]}

Biagioli, Tiziana ^{[1
]}

Barilaro, Alessandro ^{[1
]}

Urbani, Serena ^{[2
]}

Dal Pozzo, Simone ^{[2
]}

Amato, Maria Pia ^{[1
]}

Siracusa, Gianfranco ^{[1
]}

Crescioli, Clara ^{[4
]}

Manuelli, Cinzia ^{[3
]}

Bosi, A. ^{[2
]}

Saccardi, Riccardo ^{[2
]}

Massacesi, Luca ^{[1
]}

Ballerini, Clara ^{[1
]}

机构：

[1] Univ Florence, Dept Neurol Sci, I-50134 Florence, Italy

[2] Careggi Hosp, Dept Hematol, Florence, Italy

[3] Univ Florence, Dept Dermatol Sci, I-50134 Florence, Italy

[4] Univ Florence, Dept Clin Pathophysiol, Ctr High Res DENOthe, I-50134 Florence, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 199卷 / 1-2期

关键词：

MS; stem cells; chemokines; dendritic cells;

D O I：

10.1016/j.jneuroim.2008.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MSCs have been proposed as possible treatment in MS: In this Study MSCs obtained from 10 MS patients and 6 healthy donors (HD) were compared in terms of phenotypical and functional characteristics. We show that MSCs isolated from MS and HD differ significantly for IPIO production. Therefore, although MSCs isolated from MS patients exhibit the same properties of HD MSCs in terms of proliferation, phenotype, in vitro differentiation, TLR expression, immunosuppressive ability, inhibition of DC differentiation and activation, the use of autologous MSCs in cell therapy of autoimmune diseases Should be submitted to attentive evaluation and treatment. (C) 2008 Published by Elsevier B.V.

引用

页码：142 / 150

页数：9

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