Nurturing nature: engineering new antibiotics

被引：14

作者：

Kennedy, J

Hutchinson, CR

机构：

来源：

NATURE BIOTECHNOLOGY | 1999年 / 17卷 / 06期

关键词：

D O I：

10.1038/9839

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：538 / 539

页数：2

共 10 条

[1] Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis [J].

Belshaw, PJ ;

Walsh, CT ;

Stachelhaus, T .

SCIENCE, 1999, 284 (5413) :486-489

[2] Biochemistry - Harnessing the biosynthetic code: Combinations, permutations, and mutations [J].

Cane, DE ;

Walsh, CT ;

Khosla, C .

SCIENCE, 1998, 282 (5386) :63-68

[3] MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].

DONADIO, S ;

STAVER, MJ ;

MCALPINE, JB ;

SWANSON, SJ ;

KATZ, L .

SCIENCE, 1991, 252 (5006) :675-679

[4] Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis [J].

Gehring, AM ;

DeMoll, E ;

Fetherston, JD ;

Mori, I ;

Mayhew, GF ;

Blattner, FR ;

Walsh, CT ;

Perry, RD .

CHEMISTRY & BIOLOGY, 1998, 5 (10) :573-586

[5] Dissecting and exploiting intermodular communication in polyketide synthases [J].

Gokhale, RS ;

Tsuji, SY ;

Cane, DE ;

Khosla, C .

SCIENCE, 1999, 284 (5413) :482-485

[6]

KORZ D, 1999, CHEM BIOL, V6, pR39

[7] Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products [J].

McDaniel, R ;

Thamchaipenet, A ;

Gustafsson, C ;

Fu, H ;

Betlach, M ;

Ashley, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :1846-1851

[8] Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1 -: I.: Fermentation, isolation and biological activity [J].

Pacey, MS ;

Dirlam, JP ;

Geldart, RW ;

Leadlay, PF ;

McArthur, HAI ;

McCormick, EL ;

Monday, RA ;

O'Connell, TN ;

Staunton, J ;

Winchester, TJ .

JOURNAL OF ANTIBIOTICS, 1998, 51 (11) :1029-1034

[9] RATIONAL DESIGN OF PEPTIDE ANTIBIOTICS BY TARGETED REPLACEMENT OF BACTERIAL AND FUNGAL DOMAINS [J].

STACHELHAUS, T ;

SCHNEIDER, A ;

MARAHIEL, MA .

SCIENCE, 1995, 269 (5220) :69-72

[10] Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering [J].

Stassi, DL ;

Kakavas, SJ ;

Reynolds, KA ;

Gunawardana, G ;

Swanson, S ;

Zeidner, D ;

Jackson, M ;

Liu, H ;

Buko, A ;

Katz, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7305-7309

← 1 →