Fatty acid cytotoxicity to organ-cultured bovine lenses

被引：4

作者：

Glanz, D ^{[1
]}

Lennarz, B ^{[1
]}

Glaesser, D ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Physiol Chem, Fac Med, DE-06097 Halle, Germany

来源：

OPHTHALMIC RESEARCH | 2006年 / 38卷 / 02期

关键词：

lenses; bovine; organ culture; fatty acid cytotoxicity; epithelial cells; fiber cells; cataract;

D O I：

10.1159/000091389

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

High sensitivity of cultured bovine and human lens epithelial cells to unsaturated free fatty acids has been reported in previous papers. Here we show that micromolar concentrations of unsaturated free fatty acids also impair lens cells during organ culturing, a system which resembles the in vivo situation much better than cell cultures do. This added weight to the assumption that fatty acid cytotoxicity might be causally related to senile cataract as well as to cataracts associated with systemic diseases. Copyright (C) 2006 S. Karger AG, Basel.

引用

页码：62 / 65

页数：4

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