Benzoic-Imine-Based Physiological-pH-Responsive Materials for Biomedical Applications

被引：101

作者：

Qu, Xiaozhong ^{[1
,2
]}

Yang, Zhenzhong ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2016年 / 11卷 / 19期

基金：

中国国家自然科学基金;

关键词：

benzoic imines; biomedical applications; drug delivery; polymers; responsive materials; DRUG-DELIVERY SYSTEMS; MESOPOROUS SILICA NANOPARTICLES; SELF-HEALING HYDROGEL; DYNAMIC COVALENT SURFACTANTS; TUMOR-SPECIFIC UPTAKE; SITU CROSS-LINKING; CONTROLLED-RELEASE; INJECTABLE HYDROGEL; POLYMERIC MICELLES; SUPRA-AMPHIPHILES;

D O I：

10.1002/asia.201600452

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The benzoic imine is a dynamic covalent bond, which is stable around neutral pH value (ca. 7.4), but starts to hydrolyze at the extracellular pH value of solid tumors (ca. 6.5) and rapidly disintegrates at endosome and lysosome pH values (ca. 4.5-6.5). This characteristic is promising for the construction of physiological-pH-responsive materials, such as polymeric micelles, nanoparticles, and hydrogels for pharmaceutical and tissue-engineering applications. This Focus Review summarizes recent progress in the design and synthesis of pH-sensitive materials that contain the benzoic imine bond with biomedical objectives.

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收藏

页码：2633 / 2641

页数：9

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