Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori?

被引：127

作者：

Covacci, A

Falkow, S

Berg, DE

Rappuoli, R

机构：

[1] STANFORD UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,STANFORD,CA 94305

[2] NIAID,ROCKY MT LAB,NIH,HAMILTON,MT 59840

[3] WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & MOL GENET,ST LOUIS,MO 63110

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0966-842X(97)01035-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Strains of Helicobacter pylori from patients with peptic ulcer disease and gastric cancer contain a 40-kb fragment of DNA that is not present in isolates from carriers with asymptomatic infections. The discovery of the cag pathogenicity island suggests that virulence has evolved by quantum leaps through the inheritance of one or more DNA insertions.

引用

页码：205 / 208

页数：4

共 25 条

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