Embryonic transcription factors in human breast cancer

被引：23

作者：

Briegel, Karoline J. ^{[1
]}

机构：

[1] Univ Miami, Dept Biochem & Mol Biol, Miller Sch Med, Braman Family Breat Canc Inst,Sylvester Comprehen, Miami, FL 33136 USA

来源：

IUBMB LIFE | 2006年 / 58卷 / 03期

关键词：

transcription factors; embryogenesis; cell cycle; epithelial-mesenchymal transition; mammary; carcinogenesis; stem cells;

D O I：

10.1080/15216540600686870

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growing evidence suggests that breast cancer cells often reactivate latent developmental programs in order to efficiently execute the multi-step process of tumorigenesis. This review focuses on key transcriptional regulators of embryonic development that are deregulated in breast cancer and discusses the molecular mechanisms by which these proteins control carcinogenesis. Reminiscent of their function during development, embryonic transcription factors regulate changes in gene expression that promote tumor cell growth, cell survival and motility, as well as a morphogenetic process called epithelial-mesenchymal transition (EMT), which is implicated in both breast metastasis and tumor recurrence. Because of their pivotal roles in breast tumor progression, these factors represent valuable new biomarkers for breast cancer detection as well as promising new targets for anti-invasive drugs.

引用

收藏

页码：123 / 132

页数：10

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