An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

被引：103

作者：

Lourenco, Andre P. ^{[1
,2
]}

Leite-Moreira, Adelino F. ^{[1
,2
]}

Balligand, Jean-Luc ^{[3
,4
]}

Bauersachs, Johann ^{[5
]}

Dawson, Dana ^{[6
]}

de Boer, Rudolf A. ^{[7
]}

de Windt, Leon J. ^{[8
]}

Falcao-Pires, Ines ^{[1
,2
]}

Fontes-Carvalho, Ricardo ^{[1
,2
]}

Franz, Stefan ^{[9
]}

Giacca, Mauro ^{[10
,11
]}

Hilfiker-Kleiner, Denise ^{[12
]}

Hirsch, Emilio ^{[13
]}

Maack, Christoph ^{[14
]}

Mayr, Manuel ^{[15
,16
]}

Pieske, Burkert ^{[17
,18
,19
]}

Thum, Thomas ^{[20
,21
,22
]}

Tocchetti, Carlo G. ^{[23
]}

Brutsaert, Dirk L. ^{[24
]}

Heymans, Stephane ^{[25
,26
,27
,28
]}

机构：

[1] Univ Porto, Fac Med, Dept Surg & Physiol, Alameda Prof Hernini Monteiro, P-4200319 Porto, Portugal

[2] Univ Porto, Fac Med, Cardiovasc Res Ctr, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

[3] Catholic Univ Louvain, Pole Pharmacol & Therapeut, IREC, Brussels, Belgium

[4] Catholic Univ Louvain, Clin Univ St Luc, Brussels, Belgium

[5] Med Hsch, Klin Kardiol & Angiol, Hannover, Germany

[6] Univ Aberdeen, Aberdeen, Scotland

[7] Univ Groningen, Univ Med Ctr Groningen, Brigham & Womens Hosp, Boston, MA 02115 USA

[8] Maastricht Univ, CARIM Sch Cardiovasc Dis, Dept Cardiol, Fac Hlth Med & Life Sci, Maastricht, Netherlands

[9] Univ Hosp Halle, Dept Internal Med 3, Halle, Saale, Germany

[10] Univ Trieste, Mol Med Lab, ICGEB, Trieste, Italy

[11] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[12] MHH, Dept Cardiol & Angiol, Mol Cardiol, Hannover, Germany

[13] Univ Turin, Dept Mol Biotechnol & Hlth Sci, Turin, Italy

[14] Univ Klinikum Saarlandes, Klin Innere Med 3, Homburg, Germany

[15] Univ London, James Black Ctr, Kings Coll, London, England

[16] Univ London, Kings British Heart Fdn Ctr, Kings Coll, London, England

[17] Charite, Dept Cardiol, Campus Virchow, Berlin, Germany

[18] German Ctr Cardiovasc Res DZHK, Charite & Berlin Inst Hlth, Berlin, Germany

[19] Karl Franzens Univ Graz, Dept Cardiol, Graz, Austria

[20] Hannover Med Sch, IMTTS, IFB Tx, Hannover, Germany

[21] Hannover Med Sch, REBIRTH Excellence Cluster, Hannover, Germany

[22] Imperial Coll London, Natl Heart & Lung Inst, London, England

[23] Univ Naples Federico II, Dept Translat Med Sci, Div Internal Med, Naples, Italy

[24] Univ Antwerp, Antwerp, Belgium

[25] Maastricht Univ, Med Ctr, Dept Cardiol, Maastricht, Netherlands

[26] Maastricht Univ, CARIM, Maastricht, Netherlands

[27] Univ Leuven, Cardiovasc Sci, Leuven, Belgium

[28] Netherlands Heart Inst, Utrecht, Netherlands

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2018年 / 20卷 / 02期

关键词：

Heart failure with preserved ejection fraction; Animal models; Experimental evaluation; Molecular biology; Myocardial function; VENTRICULAR DIASTOLIC DYSFUNCTION; NONCARDIAC COMORBIDITIES; EXERCISE INTOLERANCE; PULMONARY-HYPERTENSION; CARDIAC STRUCTURE; CLINICAL-TRIALS; PRESSURE; STRESS; CONTRACTION; COMMUNITY;

D O I：

10.1002/ejhf.1059

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF.

引用

页码：216 / 227

页数：12

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