Endothelin ETB receptor heterodimerization: beyond the ETA receptor

被引：17

作者：

Boesen, Erika I. ^{[1
]}

机构：

[1] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA

来源：

KIDNEY INTERNATIONAL | 2008年 / 74卷 / 06期

关键词：

D O I：

10.1038/ki.2008.324

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The idea that endothelin ETA and ETB receptors may form homodimers and heterodimers has gained increasing interest in recent years. The existence of such interactions between endothelin receptors has the potential to explain some puzzling results from receptor binding and functional studies. Zeng and colleagues take ETB receptor heterodimerization beyond the ETA receptor, reporting renal endothelin ETB-dopamine D(3) receptor interactions at the cellular level that appear to have functional consequences in vivo.

引用

页码：693 / 694

页数：2

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